Dr. Konstantin Agladze
September 29, 2014
13.30 – 15.00
Beijing-1 Auditorium, China cluster (Skolkovo School of Management)
We employ tissue engineering methods for development of the experimental model of cardiac tachyarrhythmias. While a development of the new scaffold materials is of great importance for the regenerative medicine purposes, it also serves as a tool for creating the desired and realistic tissue structure: geometry, controlled inhomogeneity, gradients, etc. Here, we summarize our recent results in the study of the excitation conduction in cardiomyocyte tissue culture while controlling its excitability and structure. The tissue model enables visualization of excitation waves propagating through the cardiac syncytium using a potential-sensitive and Ca2+ -sensitive dyes. The model demonstrates its similarity to the real heart tissue, but has a much lower internal complexity. It allows study the fundamental mechanisms of cardiac re-entry originations, as well as the methods for re-entry suppression. Eventually, we discuss the prospective directions of the research with the possible outcome for regenerative medicine and pharmacological testing, based on our work performed on the human, iPS-derived cardiomyocytes.
After graduation in 1978 from the Moscow Institute of Physics and Technology (MIPT), Agladze worked at the Institute of Biological Physics, Academy of Sciences of the USSR, and then at the Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences. Since 2000 he has worked at leading research centers in the USA and Japan (University of Florida, University of North Texas Health Science Center, Emory University School of Medicine, the George Washington University (Washington, DC), Kyoto University). From 2008 to 2013 – Professor of Kyoto University, head of the laboratory in the Institute of Integrated Cell-Material Sciences. One of the winners of the first competition of mega-grants of the Russian Government in 2010. From 2011 until now – Head of the Laboratory of Biophysics of Excitable Systems in MIPT.