Prof. Paul Ducheyne.
SEMINAR «Biomaterials: Merging Materials Science with Biology»
When: November 13, 2013, 13.00 – 14.30
Where: Hypercube Auditorium, 3rd floor (Skolkovo School of Management)
SEMINAR ABSTRACT:
The last decade has seen a gradual evolution to include biological functionality in devices. Stent surfaces are modified to release rapamycin; RGD and other peptides are immobilized on device surfaces to stimulate tissue formation. Herein, we will focus on biological functionality of orthopaedic devices from several perspectives. First, in situ biological functionalization will be invoked to explain the excellent tissue response of existing biomaterials, namely the class of bioactive ceramics. Second, biological functionality achieved by controlled delivery from sol gel nanoporous controlled release materials will be discussed.
Controlled release silica sol gels are room-temperature processed, porous, resorbable materials with excellent biocompatibility. Many molecules including drugs, proteins and growth factors can be released from sol gels and the quantity and duration of the release can vary widely. Processing parameters render these release properties exquisitely versatile. Based on a thorough understanding and an extensive control of release properties, various treatment modalities for unsolved clinical problems are advancing towards the clinic. They include the treatment of osteomyelitis, the treatment of surgical pain, the treatment of MRSA and the delivery of labile growth factors.
SPEAKER INTRODUCTION:
Paul Ducheyne is Professor of Bioengineering and Professor of Orthopaedic Surgery Research at the University of Pennsylvania, Philadelphia, USA. He is the Director of its Center for Bioactive Materials and Tissue Engineering. He also is Special Guest Professor at the University of Leuven, Belgium, where he obtained his Materials Science and Engineering degrees.
Paul Ducheyne has lectured around the world and currently serves, or has served on, the editorial board of more than ten scientific journals in the biomaterials, bioceramics, bioengineering, tissue engineering, orthopaedics and dental fields. He has authored about 330 papers and chapters, and he has edited 16 books and book volumes. His papers have been cited about 9,300 times with an “h-factor” of 54; his ten most visible papers have been cited about 2,500 times. He is Editor-in Chief of Comprehensive Biomaterials, a 6-volume, 3,650-page major reference work published by Elsevier in August 2011. He has been granted more than 40 US patents with international counterparts. These patents formed the basis for various companies, including Orthovita (1992) (acquired by Stryker), Gentis (2000) and XeroThera (2013).
Paul Ducheyne has been secretary of the European Society for Biomaterials, is Past President of the Society for Biomaterials (USA) and Past President of the International Society for Ceramics in Medicine. Among other recognitions, he is a fellow of the American Association for the Advancement of Science (AAAS), he was the first Nanyang Visiting Professor at the Nanyang Institute of Technology, Singapore and he has received the C. William Hall Award from the Society for Biomaterials.
