Calibration transfer system and method

Keywords

Analytical instrumentation, calibration transfer, chemometrics

Applications

Calibration transfer between any two analytical instruments addressing the same analytical task

Problem statement

Calibration process for an analytical instrument may be long and tedious and may require the measurements with numerous standard samples which can be pretty expensive. Calibration model obtained for one instrument normally cannot be used directly with another, this leads to necessity of calibration for each particular instrument in use resulting in high costs for the maintenance.

Technology

We suggest a procedure to avoid the calibration of the second instrument with the whole set of standard samples and measure only small subset of standards instead. After that based on the results of measurements with two instruments in the same small number of standard samples a mathematical transformation is performed to adjust the signal of the second instrument into the format of the first one. This allows for using the whole calibration model of the first instrument with the data from the second instrument. Unlike other calibration transfer protocols suggested so far the present one can deal with the signals from different analytical instruments having different nature of analytical signal, different number of variables in the signal. For example calibration model from X-ray fluorescence spectrometer can be transferred to UV-Vis spectrometer.

Advantages

  • Very attractive business opportunity to sell not only the device but calibration model as well. With our new technology calibrations can be easily transferred all around the globe with just a small number of standards.
  • Significant time and money savings on calibration for the customers (e.g. only 5 standard samples instead of 20).
  • Calibration models can be transferred between old and new versions of the same device, thus the customers having older version of the instrument can save money on buying new device purchasing only the calibration instead.
  • Calibration models can be transferred between two absolutely different analytical devices.
  • Opportunity to construct a “super-calibration” which can be further transferred all around the global customers’ community addressing the same analytical task with different methods.

Inventors/Authors

  • Dr. Dmitry Kirsanov
  • Dr. Vitaly Panchuk
  • Dr. Maria Khaidukova
  • Dr. Andrey Legin

Intellectual Property

  • PCT patent application: PCT/RU2015/000378, priority date June 19, 2015

Publications

  1. V.V. Panchuk , D.O. Kirsanov , M.M. Khaydukova, V.G. Semenov, A.V. Legin, Latent Variable Based Calibration Transfer Between Different Analytical Methods, Book of Abstracts, CAC-2015, Chemometrics in Analytical Chemistry, Changsha, China, 22-26 June 2015.

Additional information

A software demo package that showcases advantages of the patent-pending algorithm is available on request.

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